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Низкокалорийная диета реально омолаживает мозг

Автор: Андрей Малыгин от 22 декабря 2019
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Группа итальянских ученых из Католического университета Святого Сердца в Риме (Catholic University of Sacred Heart in Rome) обнаружила, что при низкокалорийной диете вырабатывается белок CREB1, который активизирует гены, связанные с долголетием и нормальным функционированием головного мозга, пишет Medical Xpress.

Руководитель исследования Джовамбаттиста Пани с факультета общей патологии и медицины Католического университета совместно с коллегами провел эксперимент на лабораторных мышах, которые потребляли только 70% от обычного количества калорий. По словам специалистов, ограничение питания благотворно воздействует на организм и об этом уже давно известно.

Проведенные опыты показали, что животные дольше живут, у них не бывает ожирения и диабета, лучше развиты когнитивные функции (память, мышление, внимание) и они менее агрессивны. Кроме того, у них вообще не развивается болезнь Альцгеймера, а если и начинается, то протекает с менее выраженными симптомами, чем у перекормленных животных.

Проведенные ранее исследования уже доказали, что ожирение плохо влияет на мозг, замедляет его работу и ускоряет старение, увеличивая риск возникновения нейродегенеративных заболеваний (например, болезни Альцгеймера и Паркинсона). Однако почему ограниченное потреблений калорийной пищи полезно для мозга, до сих пор оставалось загадкой.

По данным итальянских ученых, ограничение по калориям активирует белок CREB1, который, в свою очередь, приводит в действие другую группу, связанную с долголетием. Речь идет о сиртуинах. Выводы специалистов совпадают с тем фактом, что CREB1 регулирует важные функции мозга: память и обучение. У мышей с отключенным белком ограничение в пище не давало никаких преимуществ. Они страдали от болезней нервной системы, как переедавшие и животные в возрасте.

"Таким образом, мы смогли впервые определить, как именно диета действует на мозг. Это открытие имеет важное значение для разработки эффективных методов лечения, которые позволят сохранить наш мозг молодым и предотвратить его дегенерацию и процесс старения. Кроме того, мы открыли взаимосвязь между метаболическими заболеваниями (например, диабет, ожирение) и снижением когнитивной деятельности", - комментирует Дж.Пани.

Ученые надеются, что им удастся найти способ активации CREB1, например с помощью новых лекарственных препаратов. По их мнению, это поможет сохранить молодость мозга и без строгой диеты.

Исследование ученых опубликовано в журнале Proceedings of the National Academy of Science
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